My long-term research interest has revolved around the central theme of the vital role of meaning in living the good life individually and collectively. The meaning hypothesis (MH) introduced here represents an overarching framework for my meaning-centered research and interventions. My research covers five areas: (1) The empirical foundation of meaning research, (2) Research on the meaning mindset and its effect on well-being, virtue and resilience, (3) Self-transcendence as the nexus for meaning, virtue and happiness, and (4) A three factor-model of the good life. This summary includes some of my main findings and key hypotheses for future research. My contribution to Templeton project on Virtue, Happiness and Meaning is to bring my psychological research in this area to the table of multi-disciplinary dialogue.